A native of Columbia, South Carolina, Dr. Gambrell graduated from Airport High School, with honors, in 1992. He graduated cum laude with a Bachelor of Science degree in biology from the University of South Carolina in 1996. Dr. Gambrell graduated with a Doctor of Dental Medicine degree (DMD) from the Medical University of South Carolina (MUSC), Charleston, SC in 2001.

In 2001 he was inducted into the Omicron Kappa Epsilon Honor Dental Society, which is an honor given to the top ten percent of the current dental students in the graduating class.

Dr. Gambrell stayed in Charleston the following year to complete a postgraduate residency in advanced education in general dentistry at MUSC. This residency provided extensive experience with restoring dental implants and overall comprehensive dental care. Dr. Gambrell has been a certified provider for Invisalign since 2003 and a CEREC same-day crown dentist since 2003.